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Symposium

PHARM

S02-- Tinker, Topple or Tighten? Optimization of CFTR Modulator Therapies: Right Drug, Dose & Patient

Thursday, October 8, 2026
4:30 PM - 6:30 PM EDT
Livestreamed Session
During this symposium, speakers will examine strategies to optimize CFTR modulator therapy across diverse clinical scenarios, focusing on selecting the right drug and dose for each individual patient. Through a debate-style discussion and case-based exploration, this session will highlight considerations between triple combination CFTR modulator therapies, the evolving role of therapeutic dose monitoring, and special population considerations including pregnancy and off-label use.
 


Learning Objectives:  
1. Compare the benefits and limitations of vanzacaftor/tezacaftor/deutivacaftor versus elexacaftor/tezacaftor/ivacaftor to inform individualized CFTR modulator selection
2. Discuss the role and clinical utility of therapeutic drug monitoring in optimizing CFTR modulator dosing and patient outcomes
3. Evaluate considerations for CFTR modulator use in pregnancy and off label indications

Presentation Order:


1. Alyftrek vs Trikafta Pro Con Debate – Presented by Lauren Kormelink

2. Alyftrek vs Trikafta Pro Con Debate – Presented by Jonica Huntman

3. CFTR Modulator Therapeutic Dose Monitoring – Presented by Cameron Mckinzie

4. Pregnancy and Off Label ETI Use – Presented by Wendy Bullington