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Symposium

CLIN

S22-- Clinical Equipoise in Action: Why STOP360, STOP-Peds, & REACT Matter for Everyday CF Care

Friday, October 9, 2026
2:30 PM - 4:30 PM EDT
This session brings the concept of clinical equipoise to life by exploring how pivotal studies like STOP360, STOP-Peds, and REACT are shaping everyday cystic fibrosis care. Participants will gain insight into why ongoing research remains essential—even in the era of highly effective therapies—and how these trials address critical unanswered questions in treatment decisions. Through practical examples, the session will connect research findings to real-world care, highlighting how evidence generation directly informs safer, more effective, and more personalized approaches for people with CF.

Presentation Order:


1. Why Do We Still “Double Cover” Pseudomonas in CF Pulmonary Exacerbations? The Evidence Gaps That Led to STOP360 – Presented by Ranjani Somayaji
2. Can We Safely Wait? Rethinking Immediate Antibiotics in Children: The Logic of STOP-Peds – Presented by Don Sanders
3. Pulmonary Therapies in Childhood: Do All Chronic Therapies Still Need to Continue? The Rationale Behind REACT – Presented by Margaret Rosenfeld
4. From Equipoise to Enrollment: Communication Strategies for Shared Decision Making About Enrollment – Presented by Stephanie Kraft