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Symposium

APPTT

S05-- Plugged & Infected: Mechanisms of Persistent Structural Airway Disease Despite CFTR Modulation

Thursday, October 8, 2026
4:30 PM - 6:30 PM EDT
Despite highly effective CFTR modulator therapy, many people with CF continue to experience mucus plugging, infection, and structural airway disease.
This symposium will examine mucus plugging as a heterogeneous and potentially targetable process, and will delineate mechanisms across muco-obstructive diseases, CF pathophysiology, ETI-era persistence, and the airway microbiome.

Presentation Order:


1. Mucus Plugging Across the Span of Muco-Obstructive Pulmonary Diseases – Presented by Andrew Bush
2. Mucus Plugs in CF Airway Disease – Presented by Marcus Mall
3. Persistent Airways Disease in People With CF on Modulator Therapy – Presented by Minako Furusho
4. Mucus Plugging as a Driver of Persistent CF Lung Infections – Presented by Pradeep Singh